Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.
نویسندگان
چکیده
منابع مشابه
Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.
Interleukin 1 (IL-1) may be a key mediator of inflammation and tissue damage in inflammatory bowel disease (IBD). In rabbits with immune complex-induced colitis, IL-1 alpha and beta mRNA levels were detectable at 4 h, peaked at 12 but were absent at 96 h after the induction of colitis. Colonic IL-1 tissue levels were measured by specific radioimmunoassays. IL-1 alpha was significantly elevated ...
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Interleukin-1 (IL-1) induces IL-1, tumor necrosis factor a (TNFa), and IL-6 gene expression and synthesis in a variety of cells. In this study, we investigated the ability of human recombinant IL-1 receptor antagonist (IL-lra) to inhibit IL-1induced cytokine production in human peripheral blood mononuclear cells (PBMC) and isolated monocytes. IL-lra alone at concentrations as high as 1 pg/mL di...
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Lipopolysaccharide (LPS) stimulates interleukin-1 (IL-1) and tumor necrosis factor a (TNFa) gene expression and synthesis in human peripheral blood mononuclear cells (PBMC). IL-1 can also induce PBMC to synthesize IL-I and TNFa In the present study, we used IL-1 receptor antagonist (IL-lra) to determine the relative contribution of an IL-I-positive feedback loop to the total amount of LPS-induc...
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IL-1 pretreatment prolongs survival in lethal infection in normal and in neutropenic mice. We investigated whether this protection occurs by interference with deleterious cytokine effects. The effect of IL-1 pretreatment on concentrations of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha circulating in vivo and the ex vivo cytokine production capacity of macrophages was assessed in uninfected, non-...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1990
ISSN: 0021-9738
DOI: 10.1172/jci114799